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M9471061.TXT
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1994-08-09
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Document 1061
DOCN M9471061
TI Incidence of Kaposi's sarcoma (KS), non-Hodgkin's lymphoma (NHL), and
other malignancies in a cohort of gay men with human immunodeficiency
virus (HIV) infection (Meeting abstract).
DT 9409
AU Lyter D; Bryant J; Thackeray R; Zhao P; Rinaldo C; Kingsley L; Univ. of
Pittsburgh, Div. of Medical Oncology, Pittsburgh, PA
SO Proc Annu Meet Am Soc Clin Oncol; 13:A2 1994. Unique Identifier :
AIDSLINE ICDB/94699998
AB Between October 1, 1984 and November 15, 1993, 1199 gay men were
followed by the Pitt Men's Study, the Pittsburgh component of the MACS,
a study of the natural history of HIV infection. The cohort included 769
HIV seronegative (SN) participants and 430 who were either seropositive
(SP) at enrollment or who seroconverted during the course of the study.
Cancer incidence data were collected via semi-annual visits, phone
interviews, medical records, and death certificates. 2344 person-years
and 5708 person-years were contributed to the study by the SP and SN,
respectively. In addition to 44 cases of KS in the SP and 14 NHL's (13
in SP and 1 in SN), malignancies that occurred are shown in a table.
Age-adjusted rates were calculated for both groups and compared with
rates for the general population (GP). There were no differences between
the SN and the GP. Rates of KS and NHL in the SP were 400 and 73 times
higher (respectively) as compared to the GP. The total number of other
cancers was significantly increased in the SP versus the GP, due to an
increased rate of testicular cancer. There were no significant increases
in rates of Hodgkin's disease, skin cancer or cancer of the anus in the
SP.
DE Cohort Studies Cross-Sectional Studies HIV Infections/*EPIDEMIOLOGY
Homosexuality/*STATISTICS & NUMER DATA Human Incidence Lymphoma,
AIDS-Related/*EPIDEMIOLOGY Male Neoplasms/*EPIDEMIOLOGY
Pennsylvania/EPIDEMIOLOGY Sarcoma, Kaposi's/*EPIDEMIOLOGY Skin
Neoplasms/*EPIDEMIOLOGY MEETING ABSTRACT MULTICENTER STUDY
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).